  {"id":5905,"date":"2025-03-03T11:36:43","date_gmt":"2025-03-03T17:36:43","guid":{"rendered":"https:\/\/www.vanderbilt.edu\/csb\/?p=5905"},"modified":"2025-03-03T11:38:39","modified_gmt":"2025-03-03T17:38:39","slug":"csb-research-spotlight-sanders-lab-new-mechanisms-that-cause-irregular-heartbeat","status":"publish","type":"post","link":"https:\/\/www.vanderbilt.edu\/csb\/2025\/03\/03\/csb-research-spotlight-sanders-lab-new-mechanisms-that-cause-irregular-heartbeat\/","title":{"rendered":"CSB Research Spotlight: Sanders Lab &#8211; New mechanisms that cause irregular heartbeat"},"content":{"rendered":"<p><img data-attachment-id=\"5360\" data-permalink=\"https:\/\/www.vanderbilt.edu\/csb\/2024\/06\/14\/research-spotlight-fesik-lab\/csb-research-spotlight\/\" data-orig-file=\"https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2024\/06\/14085600\/CSB-Research-Spotlight.png\" data-orig-size=\"500,300\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"CSB Research Spotlight\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2024\/06\/14085600\/CSB-Research-Spotlight-300x180.png\" data-large-file=\"https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2024\/06\/14085600\/CSB-Research-Spotlight.png\" loading=\"lazy\" class=\"alignleft wp-image-5360\" src=\"https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2024\/06\/14085600\/CSB-Research-Spotlight-300x180.png\" alt=\"\" width=\"250\" height=\"150\" srcset=\"https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2024\/06\/14085600\/CSB-Research-Spotlight-300x180.png 300w, https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2024\/06\/14085600\/CSB-Research-Spotlight.png 500w\" sizes=\"(max-width: 250px) 100vw, 250px\" \/>In a recent collaboration with researchers at Northwestern University, newly-minted PhD <strong>Kathryn Butcher (Brewer)<\/strong> and Professor of Biochemistry and Vice Dean of Basic Sciences <a href=\"https:\/\/www.vanderbilt.edu\/csb\/faculty-core\/chuck-sanders\/\" rel=\"noopener\"><strong>Chuck Sanders<\/strong><\/a> found that, for people with long QT syndrome, a heart condition that causes an irregular heartbeat, a more tailored approach to treatment could be more beneficial than the usual one-size-fits all approach.<\/p>\n<figure id=\"attachment_5907\" aria-describedby=\"caption-attachment-5907\" style=\"width: 275px\" class=\"wp-caption alignright\"><a href=\"https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2025\/03\/03111609\/Sanders_pnas.2412971122fig01-scaled.jpg\" target=\"_blank\" rel=\"noopener\"><img data-attachment-id=\"5907\" data-permalink=\"https:\/\/www.vanderbilt.edu\/csb\/2025\/03\/03\/csb-research-spotlight-sanders-lab-new-mechanisms-that-cause-irregular-heartbeat\/sanders_pnas-2412971122fig01\/\" data-orig-file=\"https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2025\/03\/03111609\/Sanders_pnas.2412971122fig01-scaled.jpg\" data-orig-size=\"2560,2077\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"Sanders_pnas.2412971122fig01\" data-image-description=\"\" data-image-caption=\"&lt;p&gt;Structural mapping of the analyzed KCNQ1 variants.&lt;\/p&gt;\n\" data-medium-file=\"https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2025\/03\/03111609\/Sanders_pnas.2412971122fig01-300x243.jpg\" data-large-file=\"https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2025\/03\/03111609\/Sanders_pnas.2412971122fig01-1024x831.jpg\" loading=\"lazy\" class=\"wp-image-5907\" src=\"https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2025\/03\/03111609\/Sanders_pnas.2412971122fig01-300x243.jpg\" alt=\"\" width=\"275\" height=\"223\" srcset=\"https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2025\/03\/03111609\/Sanders_pnas.2412971122fig01-300x243.jpg 300w, https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2025\/03\/03111609\/Sanders_pnas.2412971122fig01-1024x831.jpg 1024w, https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2025\/03\/03111609\/Sanders_pnas.2412971122fig01-768x623.jpg 768w, https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2025\/03\/03111609\/Sanders_pnas.2412971122fig01-1536x1246.jpg 1536w, https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2025\/03\/03111609\/Sanders_pnas.2412971122fig01-2048x1662.jpg 2048w\" sizes=\"(max-width: 275px) 100vw, 275px\" \/><\/a><figcaption id=\"caption-attachment-5907\" class=\"wp-caption-text\">Structural mapping of the analyzed KCNQ1 variants.<\/figcaption><\/figure>\n<p><a href=\"https:\/\/medschool.vanderbilt.edu\/basic-sciences\/2025\/02\/18\/vanderbilt-and-northwestern-labs-discover-new-mechanisms-that-cause-irregular-heartbeat\/\" target=\"_blank\" rel=\"noopener\">Read more<\/a> about the study that moves toward treatments tailored to a patient\u2019s genetic make-up.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In a recent collaboration with researchers at Northwestern University, newly-minted PhD Kathryn Butcher (Brewer) and Professor of Biochemistry and Vice Dean of Basic Sciences Chuck Sanders found that, for people with long QT syndrome, a heart condition that causes an irregular heartbeat, a more tailored approach to treatment could be more beneficial than the usual&#8230;<\/p>\n","protected":false},"author":1185,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"spay_email":"","jetpack_publicize_message":"","jetpack_is_tweetstorm":false,"jetpack_publicize_feature_enabled":true},"categories":[1],"tags":[],"acf":[],"jetpack_featured_media_url":"","jetpack_publicize_connections":[],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/posts\/5905"}],"collection":[{"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/users\/1185"}],"replies":[{"embeddable":true,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/comments?post=5905"}],"version-history":[{"count":17,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/posts\/5905\/revisions"}],"predecessor-version":[{"id":5925,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/posts\/5905\/revisions\/5925"}],"wp:attachment":[{"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/media?parent=5905"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/categories?post=5905"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/tags?post=5905"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}