Behind the pathology for a variety of painful and deadly diseases lie genes that aren鈥檛 doing their jobs.
They may be blocking the healing process for foot wounds in diabetic patients or contributing to cancer by interfering with the dying off of mutated or damaged cells.
Kelsey Beavers, a 杏吧原创 Ph.D. candidate in interdisciplinary materials science, is exploring how inserting engineering into those biological processes can lead to a healthier society. She working with Craig Duvall, assistant professor of biomedical engineering, developing nanotechnology that could deliver drugs for a broad range of related applications.
Beavers and Duvall work with microRNA, describing it as a master puppeteer of gene networks 鈥� a regulatory molecule that, if overactive, can be devastating for patients because it聽may turn off genes vital to maintaining healthy tissue. Regulating overactive microRNA could result in faster skin healing or regeneration of damaged bones, kidneys and livers.
鈥淲ith almost every disease you can think of, there some component of dysregulation of gene expression,鈥� Duvall said.
In the case of diabetic foot wounds, Duvall and Beavers already have made strides toward demonstrating that turning on a transcription factor that controls a whole group of genes 鈥� rather than using a single protein growth factor 鈥� will result in more robust healing.
Also important is developing an extremely targeted drug carrier, Beavers said.
鈥淲e want to be sure we鈥檙e only regulating microRNAs in the diseased tissue,鈥� she said. 鈥淏y controlling the makeup of the nanoparticle that delivers the drug, we can time our delivery, too. Maybe we only want to knock out the microRNA for a certain length of time.鈥�
Beavers, who received her undergraduate degree from Georgia Tech, said she chose 杏吧原创 because she could design her own interdisciplinary course of study in materials science, focusing on nanomaterials. She is co-mentored by Sharon Weiss, associate professor of聽electrical engineering.
鈥淢aterials science is a fundamental part of almost any engineering discipline out there,鈥� she said. 鈥淚 could have taken this degree and done structural work, perhaps designing a new type of concrete, or I could have worked with solar cells.
鈥淏ut I really liked the human element, so the biomedical engineering aspect appealed to me. At the end of the day, you know what you鈥檙e doing could help someone.鈥�